Good question! I don’t deliberately reject stories, but when I consider what I’ve read, yes, I do notice some biases.
Gender: I’ll follow a male protagonist as easily as a female one. Biased toward cisgender, though.
Race: I’m white and most of the stories I’ve read are white. Occasionally I’ll enjoy a story with nonwhite protagonists, but it’s just not what I’m exposed to (I’m annoyed that I only recently discovered Octavia Butler).
Culture: I’m biased toward “Western Neutral.” Not necessarily America, but it has to be a setting I can relate to. A story about an isolated tribe in the Amazon will have to work much harder to grab me than, say, a shopkeeper in Rio de Janeiro. Because even though I’m not Brazilian, I’ve worked in shops and lived in cities, so I’ll probably laugh at the protagonist’s difficult customer or gossipy coworker.
The last book I read like this was a nonfiction paperback, “Factory Girls: From Village to City in a Changing China” by Leslie T. Chang. It illustrates the experience of being a Chinese factory worker, who has far more agency than we Westerners give her credit for. And while I’ve never worked in a factory, so much of what I use has been manufactured in China that I feel like I should know who’s making it. So if it’s not a life I can relate to, it’s a life that might be connected to mine.